Journal Article

<i>In vitro</i> post-antibiotic effect of fluoroquinolones, macrolides, β-lactams, tetracyclines, vancomycin, clindamycin, linezolid, chloramphenicol, quinupristin/dalfopristin and rifampicin on <i> Bacillus anthracis</i>

A. Athamna, M. Athamna, B. Medlej, D. J. Bast and E. Rubinstein

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 53, issue 4, pages 609-615
Published in print April 2004 | ISSN: 0305-7453
Published online April 2004 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dkh130
In vitro post-antibiotic effect of fluoroquinolones, macrolides,  β-lactams, tetracyclines, vancomycin, clindamycin, linezolid, chloramphenicol, quinupristin/dalfopristin and rifampicin on  Bacillus anthracis

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Objectives: The aim of this study was to investigate in vitro the post-antibiotic effect (PAE) of 19 antibacterial agents against two strains of Bacillus anthracis (ST-1 and Sterne strains).

Methods: PAE was determined by calculating the time required for the viable counts of antibiotic-exposed bacteria (at concentrations of 10× MIC and exposure for 2 h) at 37°C to increase by 1 log10 above the counts observed immediately after antibiotic removal compared with the corresponding time for controls not exposed to antibiotics.

Results: The PAEs of the fluoroquinolones (ciprofloxacin, ofloxacin, levofloxacin, moxifloxacin and garenoxacin) were 2–5 h. The macrolide (erythromycin, clarithromycin and telithromycin) PAEs were 1–4 h, and that of clindamycin was 2 h. The PAEs induced by tetracycline and minocycline were 1–3 h. The PAEs induced by the β-lactams (penicillin G, amoxicillin and ceftriaxone), vancomycin, linezolid and chloramphenicol were 1–2 h. The PAE induced by rifampicin was 4–5 h. Quinupristin/dalfopristin had the longest PAE, lasting for 7–8 h.

Conclusions: Our results indicate that the PAE is unrelated to the MIC but may be related to the rapidity of bacterial kill. These observations may bear importance on treatment regimens of human anthrax.

Keywords: Keywords: anthrax, PAE, susceptibility

Journal Article.  2878 words.  Illustrated.

Subjects: Medical Oncology ; Critical Care

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