Journal Article

Daptomycin activity and spectrum: a worldwide sample of 6737 clinical Gram-positive organisms

Jennifer M. Streit, Ronald N. Jones and Helio S. Sader

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 53, issue 4, pages 669-674
Published in print April 2004 | ISSN: 0305-7453
Published online April 2004 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dkh143
Daptomycin activity and spectrum: a worldwide sample of  6737 clinical Gram-positive organisms

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Background: Increasing antimicrobial resistance among bacterial pathogens has prompted attempts to develop new antimicrobial agents active against multidrug-resistant Gram-positive pathogens.

Objectives: To evaluate the in vitro activity of daptomycin against a worldwide collection of clinical bacterial isolates.

Methods: Daptomycin is a novel cyclic lipopeptide recently approved by the United States Food and Drug Administration. Daptomycin and selected comparators were tested against 6737 clinical Gram-positive strains from more than 70 centres located in Europe, North America and South America.

Results: The overall distribution of daptomycin MIC values were in the range ≤0.12–8 mg/L and 99.4% of all strains were inhibited at ≤2 mg/L. Despite resistances to other antimicrobial agents, >99.9% of staphylococcal isolates were inhibited at ≤1 mg/L of daptomycin (MIC90 0.5 mg/L for staphylococci). Streptococcal isolates were very susceptible to daptomycin independent of their susceptibility to penicillin. MIC50/90 values were ≤0.12 and 0.25 mg/L, respectively. Enterococci showed the highest daptomycin MIC values, but all isolates tested were inhibited at ≤4 mg/L (except for one Enterococcus faecium isolate which showed a daptomycin MIC of 8 mg/L).

Conclusions: Daptomycin exhibited excellent in vitro activity against a wide spectrum of Gram-positive organisms and may represent a therapeutic option for infections caused by multidrug-resistant pathogens worldwide.

Keywords: Keywords: resistance, glycopeptides, multidrug-resistant

Journal Article.  3226 words. 

Subjects: Medical Oncology ; Critical Care

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