Journal Article

Potential utility of a peptide deformylase inhibitor (NVP PDF-713) against oxazolidinone-resistant or streptogramin-resistant Gram-positive organism isolates

Ronald N. Jones, Gary J. Moet, Helio S. Sader and Thomas R. Fritsche

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 53, issue 5, pages 804-807
Published in print May 2004 | ISSN: 0305-7453
Published online May 2004 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dkh184
Potential utility of a peptide deformylase inhibitor (NVP PDF-713) against oxazolidinone-resistant or streptogramin-resistant  Gram-positive organism isolates

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Objectives: To evaluate the potency of a novel peptide deformylase inhibitor, NVP PDF-713, against Gram-positive organisms having resistances to linezolid or quinupristin/dalfopristin.

Materials and methods: A total of 45 strains from three genera (six species groups) were tested by reference broth microdilution methods. The mechanism of resistance to the oxazolidinone was determined by sequencing of the gene encoding the ribosomal target.

Results: NVP PDF-713 retained activity against linezolid-resistant staphylococci (MIC range 0.25–2 mg/L), Streptococcus oralis (MIC 0.5 mg/L), Enterococcus faecalis (MIC range 2–4 mg/L) and Enterococcus faecium (MIC range 0.5–4 mg/L). Quinupristin/dalfopristin-resistant E. faecium (MIC range 1–2 mg/L) and staphylococci (MIC range 0.12–2 mg/L) were also inhibited by NVP PDF-713. Many (10 of 13 strains) of the linezolid-resistant enterococci were resistant to vancomycin and these clinical strains had a G2576U ribosomal target mutation.

Conclusions: NVP PDF-713 appears to be a promising clinical candidate among the peptide deformylase inhibitors for the treatment of infections caused by Gram-positive organisms that possess resistances to oxazolidinones or streptogramin combinations.

Keywords: Keywords: streptococci, enterococci, staphylococci, streptogramins, oxazolidinones

Journal Article.  1624 words. 

Subjects: Medical Oncology ; Critical Care

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