Journal Article

Intra-abdominal infections: review of the bacteriology, antimicrobial susceptibility and the role of ertapenem in their therapy

Ellie J. C. Goldstein and David R. Snydman

in Journal of Antimicrobial Chemotherapy

Volume 53, issue suppl_2, pages ii29-ii36
Published in print May 2004 | ISSN: 0305-7453
Published online May 2004 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dkh201
Intra-abdominal infections: review of the bacteriology, antimicrobial susceptibility and the role of ertapenem in their therapy

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Complicated intra-abdominal infections require a combination of surgery/drainage and antimicrobial therapy that is active against both the aerobic and the anaerobic bacteria that comprise the intestinal flora. Ertapenem, a parenteral carbapenem, is highly resistant to a wide variety of β-lactamase enzymes, and has a broad spectrum of activity against bacteria associated with community-acquired infections including those of complicated intra-abdominal conditions. This article reviews the bacteriology of complicated intra-abdominal infections, their antimicrobial susceptibility, especially to anaerobes, the utility of animal models in these mixed infections, and the supportive clinical trials and in vitro susceptibility data that show ertapenem to be generally well tolerated and as effective as either piperacillin–tazobactam or ceftriaxone plus metronidazole in the therapy of complicated intra-abdominal infections.

Keywords: Keywords: Bacteroides fragilis, carbapenems, intra-abdominal abscess, anaerobes, bacteriology

Journal Article.  24 words. 

Subjects: Medical Oncology ; Critical Care

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