Journal Article

Treatment of polymicrobial infections: <i>post hoc</i> analysis of three trials comparing ertapenem and piperacillin–tazobactam

Joseph Solomkin, Hedy Teppler, Donald R. Graham, Richard M. Gesser, Anne R. Meibohm, Subir Roy and Gail L. Woods

in Journal of Antimicrobial Chemotherapy

Volume 53, issue suppl_2, pages ii51-ii57
Published in print May 2004 | ISSN: 0305-7453
Published online May 2004 | e-ISSN: 1460-2091 | DOI:
Treatment of polymicrobial infections: post hoc analysis of three trials comparing ertapenem and piperacillin–tazobactam

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The efficacy of ertapenem 1 g once a day for the treatment of polymicrobial complicated intra-abdominal, complicated skin/skin-structure and acute pelvic infections was compared with piperacillin–tazobactam 3.375 g every 6 h in a post hoc analysis of data from three large randomized double-blind trials. Of the 1558 treated patients in the three trials, no pathogen was identified in 345 (22.1%), 423 (27.2%) had a monomicrobial infection and 790 (50.7%) had a polymicrobial infection. At the test-of-cure assessment, there were no significant differences in outcome between the two treatment groups for any of the three infections. Cure rates (clinical and microbiological for intra-abdominal infection, clinical for skin/skin-structure and pelvic infections) in microbiologically evaluable patients for ertapenem and piperacillin–tazobactam, respectively, were 85.6% (154/180 evaluable patients) and 82.5% (127/154) for polymicrobial intra-abdominal infection, 80.3% (53/66) and 78.7% (48/61) for polymicrobial skin/skin-structure infection, and 95.7% (88/92) and 92.6% (88/95) for polymicrobial pelvic infection. Respective cure rates for all evaluable patients in the original trials were: 83.6% and 80.4% for intra-abdominal, 83.9% and 85.3% for skin/skin-structure, and 93.9% and 91.5% for pelvic infections. These data show that in the three trials, ertapenem 1 g once a day was highly effective for the treatment of polymicrobial infections and as effective as piperacillin–tazobactam 3.375 g every 6 h.

Keywords: Keywords: mixed infections, intra-abdominal infections, skin infections, pelvic infections

Journal Article.  29 words. 

Subjects: Medical Oncology ; Critical Care

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