Journal Article

Pharmacokinetics of valaciclovir

Conan MacDougall and B. Joseph Guglielmo

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 53, issue 6, pages 899-901
Published in print June 2004 | ISSN: 0305-7453
Published online June 2004 | e-ISSN: 1460-2091 | DOI:
Pharmacokinetics of valaciclovir

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  • Medical Oncology
  • Critical Care


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While active against Herpesviridae, oral aciclovir is limited by low and inconsistent bioavailability. Modification of aciclovir by valine esterification, producing valaciclovir, results in significant increases in systemic aciclovir plasma levels. The exact mechanism of increased absorption with valaciclovir is not fully determined but probably involves intestinal dipeptide transporters, followed by rapid ester hydrolysis in the small intestine and liver. The enhanced pharmacokinetics of valaciclovir have translated into improvements in clinical efficacy and patient convenience.

Keywords: Keywords: herpesviruses, bioavailability, absorption, aciclovir

Journal Article.  2497 words.  Illustrated.

Subjects: Medical Oncology ; Critical Care

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