Journal Article

Effect of a high-molecular-weight component of cranberry on constituents of dental biofilm

Doron Steinberg, Mark Feldman, Itzhak Ofek and Ervin I. Weiss

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 54, issue 1, pages 86-89
Published in print July 2004 | ISSN: 0305-7453
Published online July 2004 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dkh254
Effect of a high-molecular-weight component of cranberry on constituents of dental biofilm

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Background: Previous studies have shown that high molecular-weight non-dialysable material derived from cranberry juice (NDM) inhibits co-aggregation of a variety of oral bacteria.

Objectives: In the present study, we examined the effect of NDM on several constituents of the dental biofilm, glucosyltransferase (GTF) and fructosyltransferase (FTF), as well as on the adhesion of Streptococcus sobrinus.

Results: The activity of immobilized and soluble GTF and FTF was inhibited by NDM (P > 0.05). NDM also inhibited adhesion of S. sobrinus to hydroxyapatite (P < 0.05).

Conclusions: Our results indicate that NDM may affect biofilm formation. One of the proposed mechanisms is via inhibition of extracellular polysaccharide synthesis, which promote the sucrose-dependent adhesion of oral bacteria as S. sobrinus.

Keywords: mutans streptococci; anti-adhesion; glucosyltransferases; fructosyltransferases

Journal Article.  2431 words.  Illustrated.

Subjects: Medical Oncology ; Critical Care

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