Journal Article

Nitroimidazole resistance genes (<i>nimB</i>) in anaerobic Gram-positive cocci (previously <i>Peptostreptococcus</i> spp.)

Maria M. Theron, Marais N. Janse van Rensburg and Lynda J. Chalkley

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 54, issue 1, pages 240-242
Published in print July 2004 | ISSN: 0305-7453
Published online July 2004 | e-ISSN: 1460-2091 | DOI:
Nitroimidazole resistance genes (nimB) in anaerobic Gram-positive cocci (previously Peptostreptococcus spp.)

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Objectives: To investigate metronidazole resistance and the prevalence of nitroimidazole (nim) genes in clinically isolated anaerobic Gram-positive cocci.

Methods: Metronidazole susceptibility was determined in 99 strains of anaerobic Gram-positive cocci and PCR amplification for the nim gene carried out on 61 strains (metronidazole MIC ≥0.5 mg/L).

Results: The nimB gene was detected in 34% (21/61) of the strains. These included two highly resistant Finegoldia magna strains (MICs >128 mg/L). The nimB gene was, however, also demonstrated in 90% (19/21) of susceptible strains.

Conclusions: Although the nimB gene may be implicated in the high-level metronidazole resistance in 2 F. magna strains, the alarmingly high prevalence of the nimB gene in anaerobic Gram-positive cocci cannot be directly associated with resistance and the possibility of a silent nimB gene should be considered.

Keywords: anaerobic Gram-positive cocci; metronidazole resistance; nim genes

Journal Article.  1370 words. 

Subjects: Medical Oncology ; Critical Care

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