Journal Article

Post-exposure prophylaxis of systemic anthrax in mice and treatment with fluoroquinolones

J. Steward, M. S. Lever, A. J. H. Simpson, A. M. Sefton and T. J. G. Brooks

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 54, issue 1, pages 95-99
Published in print July 2004 | ISSN: 0305-7453
Published online July 2004 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dkh276
Post-exposure prophylaxis of systemic anthrax in mice and treatment with fluoroquinolones

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Objectives: To compare the fluoroquinolones gatifloxacin and moxifloxacin with ciprofloxacin for post-exposure prophylaxis of systemic anthrax in a BALB/c mouse model.

Methods: Treated mice and controls were inoculated subcutaneously with 5×104 spores/mouse of Bacillus anthracis Ames strain and observed for 37 days after challenge. Treated mice were given 100 mg/kg of antibiotic orally twice daily for 14 days, starting at various times post-challenge.

Results: Treatment starting 6 h post-challenge resulted in survival rates of 90%, 15% and 40% for gatifloxacin, moxifloxacin and ciprofloxacin, respectively. Treatment commencing 24 h post-challenge resulted in survival rates of 65%, 10% and 5%, respectively. Treatment starting more than 24 h after exposure had little effect on survival.

Conclusions: Gatifloxacin appeared to be more effective than moxifloxacin or ciprofloxacin, at similar doses, for early post-exposure treatment of murine systemic anthrax. However, these results might be due to differences in potency or pharmacokinetic properties.

Keywords: Bacillus anthracis; quinolones; murine model; therapy

Journal Article.  3745 words.  Illustrated.

Subjects: Medical Oncology ; Critical Care

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