Journal Article

Disposition of voriconazole during continuous veno-venous haemodiafiltration (CVVHDF) in a single patient

C. Robatel, M. Rusca, C. Padoin, O. Marchetti, L. Liaudet and T. Buclin

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 54, issue 1, pages 269-270
Published in print July 2004 | ISSN: 0305-7453
Published online July 2004 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dkh310
Disposition of voriconazole during continuous veno-venous haemodiafiltration (CVVHDF) in a single patient

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Objectives: To determine whether voriconazole dosage adjustment is required during continuous veno-venous haemodiafiltration (CVVHDF).

Methods: Voriconazole pharmacokinetics were studied in a critically ill patient under CVVHDF. The analysis was carried out for 12 h following a 6 mg/kg dose. Voriconazole concentrations were measured by HPLC in blood inlet and outlet lines and in dialysate.

Results: The total body clearance of voriconazole was 20.3 L/h, with a terminal half-life of 13.7 h and a distribution volume of 399 L. The estimated sieving coefficient was 0.53 and the filtration-dialysis clearance 1.2 L/h.

Conclusions: CVVHDF does not significantly affect voriconazole disposition and requires no dosage adjustment.

Keywords: antifungals; renal failure; dialysis; pharmacokinetics

Journal Article.  1096 words.  Illustrated.

Subjects: Medical Oncology ; Critical Care

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