Journal Article

Anomaly and correlation of killing in the therapeutic properties of silver (I) chelation with glutamic and tartaric acids

Kareen I. Batarseh

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 54, issue 2, pages 546-548
Published in print August 2004 | ISSN: 0305-7453
Published online August 2004 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dkh349
Anomaly and correlation of killing in the therapeutic properties of silver (I) chelation with glutamic and tartaric acids

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Objectives: To investigate whether silver chelates or silver ions are more effective as therapeutic agents, and to examine their mode of action so that safer and stable compounds that have a broad spectrum of therapeutic activities can be developed.

Methods: Efficacy was investigated against Pseudomonas aeruginosa (ATCC 15442) by determining MIC via a broth macrodilution procedure using NCCLS methods for antibiotic susceptibility testing.

Results: It was found that the responsible agent for silver therapeutic properties is the silver chelates rather than silver ions, contradicting previous findings, and the efficacy profiles mimic that of free silver ions present in solution.

Conclusions: Silver therapeutic activities seem to be more effective as complexes—an intracellular package—rather than free silver ions, demonstrating that the effect of silver is linked to cells' DNA unwinding, and not respiratory or membrane functionality as was traditionally recognized.

Keywords: oligodynamics; silver; antimicrobials; chemotherapeutics; DNA

Journal Article.  1773 words. 

Subjects: Medical Oncology ; Critical Care

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