Journal Article

Survey, characterization and susceptibility to fusidic acid of <i>Staphylococcus aureus</i> in the Carmarthen area

D. El-Zimaity, A. M. Kearns, S. J. Dawson, S. Price and G. A. J. Harrison

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 54, issue 2, pages 441-446
Published in print August 2004 | ISSN: 0305-7453
Published online August 2004 | e-ISSN: 1460-2091 | DOI:
Survey, characterization and susceptibility to fusidic acid of Staphylococcus aureus in the Carmarthen area

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Objective: This retrospective study was designed to investigate the possible reasons for an apparent increase in fusidic acid resistance among Staphylococcus aureus.

Materials and methods: The Datastore records of the Communicable Disease Surveillance Centre, Wales, UK were reviewed in conjunction with information concerning the prescribing of fusidic acid.

Results: During the 5 year study period (1997–2001), a rise in the incidence of fusidic acid resistance was noted, particularly among paediatric patients presenting with infected eczema and impetigo, which may be related to the observed increase in prescriptions of topical fusidic acid. Extended phenotypic and genotypic characterization of a limited number (n=31) of isolates from 2002 showed that fusidic acid-resistant strains of S. aureus were typically from patients with impetigo and isolates fell into a single clonal group. Conversely, isolates from other skin disease (eczema, dermatitis and abscesses) were usually susceptible to fusidic acid and proved a diverse group.

Conclusion: This study provides valuable data on the prevalence of fusidic acid-resistant S. aureus, the genetic background of the strains, and their association with clinical disease in both the healthcare environment and community setting in the catchment area served by the Laboratory.

Keywords: impetigo; infections; dermatological infections; antibiotic resistance

Journal Article.  3386 words.  Illustrated.

Subjects: Medical Oncology ; Critical Care

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