Journal Article

Impact of highly active antiretroviral therapy on incidence and management of human immunodeficiency virus-related opportunistic infections

Chien-Ching Hung and Shan-Chwen Chang

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 54, issue 5, pages 849-853
Published in print November 2004 | ISSN: 0305-7453
Published online November 2004 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dkh438
Impact of highly active antiretroviral therapy on incidence and management of human immunodeficiency virus-related opportunistic infections

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We review the changes in incidences of HIV-related opportunistic infections and the safety of discontinuation of primary and secondary prophylaxis for HIV-related opportunistic infections in patients achieving immune restoration after the introduction of highly active antiretroviral therapy (HAART). HIV-related opportunistic infections continue to occur in patients who are newly diagnosed with HIV infection, those in the early course of HAART or non-adherent to HIV care and HAART, and those in whom non-HIV-related infections have emerged as a significant cause of morbidity and mortality in the post-HAART era. Clinical studies of patients with tuberculosis and HIV co-infection are reviewed to provide appropriate regimen combinations of rifamycins and antiretrovirals, which have varying degrees of drug–drug interactions that have posed challenges in the management of tuberculosis as well as HIV infection.

Keywords: HIV infection; AIDS; HAART; opportunistic infections; antimicrobial prophylaxis

Journal Article.  4341 words. 

Subjects: Medical Oncology ; Critical Care

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