Journal Article

Increase and change in pattern of hospital antimicrobial use, Denmark, 1997–2001

Berit Müller-Pebody, Mark Muscat, Benjamin Pelle, Bjarke M. Klein, Christian T. Brandt and Dominique L. Monnet

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 54, issue 6, pages 1122-1126
Published in print December 2004 | ISSN: 0305-7453
Published online December 2004 | e-ISSN: 1460-2091 | DOI:
Increase and change in pattern of hospital antimicrobial use, Denmark, 1997–2001

More Like This

Show all results sharing these subjects:

  • Medical Oncology
  • Critical Care


Show Summary Details


Objectives: To analyse the changes and compare antimicrobial consumption in public hospitals in Denmark over the period 1997–2001.

Methods: Data on the number of WHO defined daily doses (DDD) were obtained from the Danish Medicines Agency. Data on the number of bed-days were obtained from the National Board of Health. We calculated antimicrobial consumption in hospitals as the number of DDD per 100 bed-days for all antibacterials for systemic use i.e. group J01 of the Anatomical Therapeutic Chemical (ATC) classification and for classes of this group.

Results: During 1997–2001, antimicrobial use in hospitals in Denmark significantly increased by 18%, from 38.0 to 44.8 DDD per 100 bed-days (P < 0.005). Most of this increase (55%) was attributed to an increase in consumption of commonly used classes of antimicrobials, mainly penicillins with extended spectrum (ATC group J01CA), β-lactamase-sensitive penicillins (J01CE) and β-lactamase-resistant penicillins (J01CF). The ‘broad-spectrum’ and newer antimicrobials, i.e. combinations of penicillins with β-lactamase inhibitor (J01CR), cephalosporins (J01DA), carbapenems (J01DH) and fluoroquinolones (J01MA) contributed to 36% of the increase. Together, these amounted to 16% of total consumption in hospitals in Denmark in 1997, rising to 19% in 2001.

Conclusions: Although antimicrobial consumption in public hospitals in Denmark is low compared with other countries, the steady increase and change in pattern of their use are causes of concern, deserving close monitoring and further investigations.

Keywords: antibiotics, drug utilization, surveillance

Journal Article.  2820 words.  Illustrated.

Subjects: Medical Oncology ; Critical Care

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.