Journal Article

Pyridine N-oxide derivatives: unusual anti-HIV compounds with multiple mechanisms of antiviral action

Jan Balzarini, Miguel Stevens, Erik De Clercq, Dominique Schols and Christophe Pannecouque

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 55, issue 2, pages 135-138
Published in print February 2005 | ISSN: 0305-7453
Published online February 2005 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dkh530
Pyridine N-oxide derivatives: unusual anti-HIV compounds with multiple mechanisms of antiviral action

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Pyridine N-oxide derivatives represent a new class of anti-HIV compounds, for which some members exclusively act through inhibition of HIV-1 reverse transcriptase and thus characteristically behave as non-nucleoside reverse transcriptase inhibitors. Other members act, additionally or alternatively, at a post-integrational event in the replication cycle of HIV, that is, at the level of HIV gene expression. Repeated administration of one of the prototype compounds (JPL-32) to DBA/2 and hu-PBMC-SCID mice demonstrated, in the absence of any acute toxicity, protective activity against HIV-induced destruction of CD4 human T lymphocytes.

Keywords: NF-κB; reverse transcriptase; NNRTI;transcription inhibitors; HIV chemotherapy

Journal Article.  1991 words.  Illustrated.

Subjects: Medical Oncology ; Critical Care

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