Journal Article

<i>In vitro</i> susceptibilities of bloodstream isolates of <i>Candida</i> species to six antifungal agents: results from a population-based active surveillance programme, Barcelona, Spain, 2002–2003

Manuel Cuenca-Estrella, Dolores Rodriguez, Benito Almirante, Juliette Morgan, Ana Maria Planes, Manel Almela, José Mensa, Ferran Sanchez, Josefina Ayats, Montserrat Gimenez, Margarita Salvado, David W. Warnock, Albert Pahissa and Juan L. Rodriguez-Tudela

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 55, issue 2, pages 194-199
Published in print February 2005 | ISSN: 0305-7453
Published online February 2005 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dkh548
In vitro susceptibilities of bloodstream isolates of Candida species to six antifungal agents: results from a population-based active surveillance programme, Barcelona, Spain, 2002–2003

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Objectives:

The antifungal drug susceptibilities of 351 isolates of Candida species, obtained through active laboratory-based surveillance in the period January 2002–December 2003, were determined (Candida albicans 51%, Candida parapsilosis 23%, Candida tropicalis 10%, Candida glabrata 9%, Candida krusei 4%).

Methods:

The MICs of amphotericin B, flucytosine, fluconazole, itraconazole, voriconazole and caspofungin were established by means of the broth microdilution reference procedure of the European Committee on Antibiotic Susceptibility Testing.

Results and conclusions:

Amphotericin B and flucytosine were active in vitro against all strains. A total of 24 isolates (6.8%) showed decreased susceptibility to fluconazole (MIC ≥ 16 mg/L) and 43 (12.3%) showed decreased susceptibility to itraconazole (MIC ≥ 0.25 mg/L). Voriconazole and caspofungin were active in vitro against the majority of isolates, even those that were resistant to fluconazole.

Keywords: fluconazole resistance; caspofungin; voriconazole; EUCAST

Journal Article.  3668 words. 

Subjects: Medical Oncology ; Critical Care

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