Journal Article

Oseltamivir (Tamiflu<sup>®</sup>) and its potential for use in the event of an influenza pandemic

Penelope Ward, Ian Small, James Smith, Pia Suter and Regina Dutkowski

in Journal of Antimicrobial Chemotherapy

Volume 55, issue suppl_1, pages i5-i21
Published in print February 2005 | ISSN: 0305-7453
Published online February 2005 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dki018
Oseltamivir (Tamiflu®) and its potential for use in the event of an influenza pandemic

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Recent cross species transmission of avian influenza has highlighted the threat of pandemic influenza. Oseltamivir (Tamiflu®) has been shown to be effective in the treatment and prevention of epidemic influenza infection in adults, adolescents and children (≥ 1 year). Although oseltamivir has not been approved for prophylactic use in children, it has been shown to be effective. Oseltamivir is also active against avian influenza virus strains. Evidence suggests that lower doses or shorter durations of treatment/chemoprophylaxis other than those approved may not be effective and may contribute to emergence of viral resistance. Safety data from dose ranging studies show that 5 day courses of 150 mg twice daily for treatment and 6 week courses of 75 mg twice daily for prophylaxis were as well tolerated as the approved dose regimens. The use of oseltamivir in a pandemic is influenced by the goals of the pandemic plan developed by the responsible Government and Health Authority. To optimize use of antiviral medications, processes will be needed to collect, collate and report outcome data from treated patients and/or from use for chemoprophylaxis of pandemic influenza during the first-wave outbreaks. If oseltamivir is included in a national or regional pandemic plan, stockpiling of the material, either in the form of capsules or the bulk active pharmaceutical ingredient will be necessary. In the absence of a stockpile, there is no guarantee that an adequate supply of oseltamivir will be available.

Keywords: treatment; therapy; neuraminidase inhibitors

Journal Article.  0 words. 

Subjects: Medical Oncology ; Critical Care

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