Journal Article

Antifungal activity of posaconazole compared with fluconazole and amphotericin B against yeasts from oropharyngeal candidiasis and other infections

Alfonso-Javier Carrillo-Muñoz, Guillermo Quindós, Maite Ruesga, Rocío Alonso, Oscar del Valle, Juan Manuel Hernández-Molina, Paul McNicholas, David Loebenberg and Patricia Santos

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 55, issue 3, pages 317-319
Published in print March 2005 | ISSN: 0305-7453
Published online March 2005 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dki022
Antifungal activity of posaconazole compared with fluconazole and amphotericin B against yeasts from oropharyngeal candidiasis and other infections

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Objectives: The in vitro antifungal activity of posaconazole was compared with that of fluconazole and amphotericin B.

Materials and methods: A microdilution method (M27-A2) was used with 331 clinical yeast isolates.

Results: The geometric mean MICs of posaconazole, fluconazole and amphotericin B were 0.16, 0.91 and 0.15 mg/L, respectively. Posaconazole was markedly more active than fluconazole and was active against 9/11 fluconazole-resistant Candida albicans, and five Candida glabrata had an MIC of posaconazole of 16 mg/L.

Conclusions: These data indicate that posaconazole is a potentially effective antifungal agent for the treatment of mycoses caused by yeasts.

Keywords: susceptibility; opportunistic; Candida

Journal Article.  1970 words. 

Subjects: Medical Oncology ; Critical Care

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