Journal Article

Efficacy of micafungin against deep-seated candidiasis in cyclophosphamide-induced immunosuppressed mice

Mochiyoshi Ninomiya, Hiroshige Mikamo, Kaori Tanaka, Kunitomo Watanabe and Teruhiko Tamaya

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 55, issue 4, pages 587-590
Published in print April 2005 | ISSN: 0305-7453
Published online April 2005 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dki024
Efficacy of micafungin against deep-seated candidiasis in cyclophosphamide-induced immunosuppressed mice

Show Summary Details

Preview

Objectives: We investigated the effects of fluconazole and micafungin for the therapy of deep-seated candidiasis in a cyclophosphamide-induced immunosuppressed mouse model.

Methods: We used the experimental model of intraperitoneal fungal abscess caused by Candida albicans, as described previously.

Results and conclusions: Micafungin efficacy was equal to that of fluconazole in one-tenth dosage even in peritonitis. We also assessed the short-term (24 h) and long-term (8 days) therapeutic effects after the end of therapy. Although the therapeutic effect of fluconazole was similar to that of micafungin at 24 h after the end of therapy, the effect of micafungin was superior to that of fluconazole at 8 days after the end of therapy.

Keywords: micafungin; fluconazole; experimental infection; Candida albicans

Journal Article.  1676 words.  Illustrated.

Subjects: Medical Oncology ; Critical Care

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.