Journal Article

A simplified strategy for clinical management of late cytomegalovirus infection after oral ganciclovir prophylaxis in renal recipients

Dirk R. J. Kuypers, Kathleen Claes, Pieter Evenepoel, Bart Maes and Yves Vanrenterghem

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 55, issue 3, pages 391-394
Published in print March 2005 | ISSN: 0305-7453
Published online March 2005 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dki031
A simplified strategy for clinical management of late cytomegalovirus infection after oral ganciclovir prophylaxis in renal recipients

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  • Medical Oncology
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Objectives: Late cytomegalovirus disease after completion of prophylactic therapy occurs in 5–21% of renal allograft recipients within the first year post-transplantation. Identifying patients at risk for late infection is clinically difficult; prolonged cytomegalovirus (CMV) monitoring is costly and cumbersome as follow-up intervals lengthen.

Patients and methods: We performed a prospective 1 year study in 54 de novo renal recipients to assess the minimum CMV monitoring frequency for identifying patients at risk.

Results and conclusions: CMV DNA PCR monitoring on the last day, and again 2 weeks after conclusion of oral ganciclovir prophylaxis, seemed sufficient for identifying recipients at risk for developing clinically relevant late CMV disease and for whom closer clinical follow-up is warranted.

Keywords: CMV infection; CMV disease; CMV prophylaxis; CMV monitoring; kidney transplantation

Journal Article.  2241 words.  Illustrated.

Subjects: Medical Oncology ; Critical Care

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