Journal Article

The latent HIV-1 reservoir in patients undergoing HAART: an archive of pre-HAART drug resistance

Ann Noë, Jean Plum and Chris Verhofstede

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 55, issue 4, pages 410-412
Published in print April 2005 | ISSN: 0305-7453
Published online April 2005 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dki038
The latent HIV-1 reservoir in patients undergoing HAART: an archive of pre-HAART drug resistance

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  • Medical Oncology
  • Critical Care

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Recent studies on patients with a history of pre-HAART drug resistance, but currently on a successful regimen, provided new insights into the dynamics of the latent cellular viral reservoir. Results indicated that the latent reservoir is an archive, composed of a mixture of wild-type and drug-resistant strains. The studies showed that, even after years of successful HAART, the wild-type viral strains that circulated before the initiation of the therapy as well as all the different drug-resistant viral strains that evolved over time during eventual periods of non-suppressive treatment, remain detectable in the proviral reservoir. These findings support the hypothesis that during active viral replication, new variants, including drug-resistant ones, continuously enter the latent viral reservoir. It can be concluded that, as a consequence of the lifelong conservation of this latent reservoir, the potency of drugs for which resistance once developed will remain reduced, even after years of withdrawal of the drug.

Keywords: reservoirs of resistance; mechanisms of resistance; mutations

Journal Article.  2022 words. 

Subjects: Medical Oncology ; Critical Care

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