Journal Article

Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs: an update

Johan W. Mouton, Michael N. Dudley, Otto Cars, Hartmut Derendorf and George L. Drusano

in Journal of Antimicrobial Chemotherapy

Volume 55, issue 5, pages 601-607
Published in print May 2005 | ISSN: 0305-7453
Published online May 2005 | e-ISSN: 1460-2091 | DOI: https://dx.doi.org/10.1093/jac/dki079
Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs: an update

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  • Medical Oncology
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Interest in the relationships between the pharmacokinetics (PK) and pharmacodynamics (PD) of antimicrobial agents has increased over recent years. Since the appearance 2 years ago of our first article describing terminology in PK/PD, the field has continued to expand rapidly, urgently requiring an update. This paper describes in a uniform manner the use of PK/PD expressions for antimicrobial agents, and their units.

Keywords: AUC/MIC; T>MIC; probability of target attainment; cumulative fraction of response; protein binding

Journal Article.  4210 words. 

Subjects: Medical Oncology ; Critical Care

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