Journal Article

Combination of nucleoside analogues in the treatment of chronic hepatitis B virus infection: lesson from experimental models

Fabien Zoulim

in Journal of Antimicrobial Chemotherapy

Volume 55, issue 5, pages 608-611
Published in print May 2005 | ISSN: 0305-7453
Published online May 2005 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dki095
Combination of nucleoside analogues in the treatment of chronic hepatitis B virus infection: lesson from experimental models

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Owing to the persistence of hepatitis B virus (HBV) and the selection of drug-resistant mutants, a new concept of antiviral therapy for chronic hepatitis B relies on the combination of nucleoside analogues. In experimental models of HBV infection, several key points concerning these combinations were addressed. (i) Is it possible to achieve a synergic antiviral effect with polymerase inhibitors? (ii) Is it possible to impact on intracellular viral covalently closed circular DNA? (iii) What is the impact of the cross-resistance patterns of the different nucleoside analogues? (iv) What is the effect of viral load suppression on the restoration of specific antiviral cellular responses? The clinical impact of these key issues is discussed in the perspective of new clinical trials.

Keywords: HBV; antiviral; therapy

Journal Article.  2863 words. 

Subjects: Medical Oncology ; Critical Care

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