Journal Article

Drug resistance and antiretroviral drug development

Robert W. Shafer and Jonathan M. Schapiro

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 55, issue 6, pages 817-820
Published in print June 2005 | ISSN: 0305-7453
Published online April 2005 | e-ISSN: 1460-2091 | DOI:
Drug resistance and antiretroviral drug development

Show Summary Details


As more drugs for treating HIV have become available, drug resistance profiles within antiretroviral drug classes have become increasingly important for researchers developing new drugs and for clinicians integrating new drugs into their clinical practice. In vitro passage experiments and comprehensive phenotypic susceptibility testing are used for the pre-clinical evaluation of drug resistance. Clinical studies are required, however, to delineate the full spectrum of mutations responsible for resistance to a new drug and to identify the settings in which a new drug is likely to be most useful for salvage therapy.

Keywords: HIV; profiles; antivirals; clinical studies; genotype; phenotype

Journal Article.  3539 words. 

Subjects: Medical Oncology ; Critical Care

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