Journal Article

A 6 week course of azithromycin treatment has no beneficial effect on atherosclerotic lesion development in apolipoprotein E-deficient mice chronically infected with <i>Chlamydia pneumoniae</i>

E. Blessing, L. A. Campbell, M. E. Rosenfeld, B. Chesebro and C.-C. Kuo

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 55, issue 6, pages 1037-1040
Published in print June 2005 | ISSN: 0305-7453
Published online June 2005 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dki128
A 6 week course of azithromycin treatment has no beneficial effect on atherosclerotic lesion development in apolipoprotein E-deficient mice chronically infected with Chlamydia pneumoniae

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Objectives: To evaluate whether antimicrobial chemotherapy prevents acceleration of atherosclerotic lesion development induced by infection with Chlamydia pneumoniae.

Methods: ApoE-deficient mice which develop hyperlipidaemia and atherosclerosis spontaneously were inoculated intranasally with C. pneumoniae. Animals were treated with azithromycin for 6 weeks after the third inoculation and the atherosclerotic lesion areas in the aortic sinus were measured by computer-assisted morphometry.

Results: At 12 weeks post-infection, infected untreated animals developed significantly larger lesion areas compared with sham-inoculated controls (8.7 × 104±2.3 × 104 μm2 versus 5.6 × 104±2.4 × 104 μm2). However, there were no differences in lesion size of infected mice treated with azithromycin in comparison with untreated infected controls (11.0 × 104±3.0 × 104 μm2 versus 8.7 × 104±2.3 × 104 μm2).

Conclusions: Antibiotic treatment against C. pneumoniae has no beneficial effects on hyperlipidaemia-induced atherosclerosis accelerated by C. pneumoniae in a mouse model.

Keywords: C. pneumoniae; atherosclerosis; hyperlipidaemia; treatment; prevention

Journal Article.  1883 words.  Illustrated.

Subjects: Medical Oncology ; Critical Care

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