Journal Article

Risk factors for antibiotic-resistant <i>Escherichia coli</i> isolated from community-acquired urinary tract infections in Dakar, Senegal

Jacques Albert Dromigny, Pierre Nabeth, Ann Juergens-Behr and Jean David Perrier-Gros-Claude

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 56, issue 1, pages 236-239
Published in print July 2005 | ISSN: 0305-7453
Published online April 2005 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dki158
Risk factors for antibiotic-resistant Escherichia coli isolated from community-acquired urinary tract infections in Dakar, Senegal

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Objectives: To assess overall resistance rates and risk factors for resistance to ampicillin, co-amoxiclav, nalidixic acid, fluoroquinolones and trimethoprim/sulfamethoxazole in Escherichia coli strains isolated from outpatients with acute urinary tract infection in Dakar (Senegal).

Patients and methods: From June 2001 to June 2003, a prospective study was performed among Senegalese outpatients consulting at the Institut Pasteur of Dakar for urine analysis. Evaluated risk factors were: age, gender, prior hospitalization, antibiotic exposure, urinary tract infection and urinary catheter.

Results: A total of 398 non-duplicate, consecutive, biologically significant E. coli were isolated. The levels of antibiotic resistance in Dakar appeared dramatic and worrisome with resistance rates ranging from 18.6% for fluoroquinolones to 73.6% for ampicillin. With the exception of the presence of urinary catheter, the risk factors identified were consistent with data previously reported in developed countries.

Conclusions: We hope our results will assist medical authorities in the development of appropriate control strategies.

Keywords: antimicrobial resistance; multivariate analysis; Enterobacteriaceae

Journal Article.  2077 words. 

Subjects: Medical Oncology ; Critical Care

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