Journal Article

Effect of intermittent inhaled tobramycin on sputum cytokine profiles in cystic fibrosis

M. O. Husson, N. Wizla-Derambure, D. Turck, P. Gosset and B. Wallaert

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 56, issue 1, pages 247-249
Published in print July 2005 | ISSN: 0305-7453
Published online June 2005 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dki179
Effect of intermittent inhaled tobramycin on sputum cytokine profiles in cystic fibrosis

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Objectives: The aim of this study was to evaluate the anti-inflammatory properties of intermittent inhaled tobramycin.

Methods: To establish this, we initiated a prospective study to measure the concentration of the three pro-inflammatory cytokines IL-8, IL-6 and TNF-α in the sputum from 20 cystic fibrosis (CF) patients (15 teenagers and 5 young adults) during cycles and off cycles.

Results: A significant decrease in IL-8 (P = 0.001) and a more moderate decrease in IL-6 (P = 0.046) and TNF-α (P = 0.052) levels were observed during cycles, even if no significant decrease in the number of leucocytes was observed.

Conclusions: These results associated with a decrease in the Pseudomonas aeruginosa population can contribute in part to the beneficial effect of intermittent inhaled tobramycin on pulmonary function.

Keywords: Pseudomonas aeruginosa; IL-8; IL-6; TNF-α

Journal Article.  1247 words.  Illustrated.

Subjects: Medical Oncology ; Critical Care

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