Journal Article

Defining invasive fungal infections in neutropenic or stem cell transplant patients

Chris Kibbler

in Journal of Antimicrobial Chemotherapy

Volume 56, issue suppl_1, pages i12-i16
Published in print September 2005 | ISSN: 0305-7453
Published online September 2005 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dki219
Defining invasive fungal infections in neutropenic or stem cell transplant patients

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Consistent definition of invasive fungal infection is important for managing individual patients, for conducting clinical trials and for evaluating diagnostic tests. However, a recent systematic review of the literature found that at least 25 adverbs have been used to categorize infections and when the criteria in these papers were applied to a single database of patients with fungal infections, there was little agreement. This is the consequence of the varying sensitivity and specificity of different clinical features and investigations in different patient groups and an inconsistency in their application. This review examines the clinical presentation of invasive fungal infections in neutropenic patients and those receiving stem cell transplants, as well as the performance of currently available investigations, in order to consider their value as invasive fungal infection criteria. The recent publication of the European Organization for Research and Treatment of Cancer/Mycoses Study Group (EORTC/MSG) definitions has provided an international standard for the performance of clinical research in this group of patients. The definitions committee has now been reconvened to consider some of the criticisms of the original criteria and these are likely to evolve further in the future.

Keywords: invasive aspergillosis; CT scanning; galactomannan

Journal Article.  0 words. 

Subjects: Medical Oncology ; Critical Care

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