Journal Article

Efficacy of β-lactams against experimental pneumococcal endocarditis caused by strains with different susceptibilities to penicillin

Cristina Pichardo, Fernando Docobo-Pérez, Maria E. Pachón-Ibáñez, Manuel E. Jiménez-Mejías, Andrés García-Curiel, F. Javier Caballero-Granado, Ignacio Moreno-Maqueda and Jerónimo Pachón

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 56, issue 4, pages 732-737
Published in print October 2005 | ISSN: 0305-7453
Published online September 2005 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dki304
Efficacy of β-lactams against experimental pneumococcal endocarditis caused by strains with different susceptibilities to penicillin

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Objectives: To compare the in vitro and in vivo activity of penicillin, cefotaxime and ceftriaxone, using three strains of Streptococcus pneumoniae with different susceptibilities to penicillin (MICs of 0.015, 0.25 and 2 mg/L, respectively).

Methods: Time–kill curves and an experimental model of endocarditis in rabbits.

Results: Penicillin was efficacious in clearing bacteria from vegetations and blood irrespective of whether infections were caused by penicillin-susceptible or penicillin-resistant strains (P < 0.01 with respect to control groups). The same efficacy was shown with cefotaxime and ceftriaxone. Comparing the results of the in vivo model with those obtained in time–kill curves, penicillin showed the best results.

Conclusions: These results confirm that penicillin is efficacious in the treatment of pneumococcal infections, including those produced by strains with MICs ≤ 2 mg/L (with the exception of pneumococcal meningitis). These results also suggest that the breakpoints to define susceptibility and resistance of S. pneumoniae to penicillin must be reviewed, as has been done with amoxicillin and third-generation cephalosporins.

Keywords: Streptococcus pneumoniae; antimicrobial resistance; antimicrobial therapy

Journal Article.  3752 words.  Illustrated.

Subjects: Medical Oncology ; Critical Care

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