Journal Article

Successful moxifloxacin prophylaxis against experimental streptococcal aortic valve endocarditis

Vissaria Sakka, Lambrini Galani, Angelos Pefanis, Dimitrios Iliopoulos, George Athanasopoulos, Ismini Donta and Helen Giamarellou

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 56, issue 6, pages 1160-1162
Published in print December 2005 | ISSN: 0305-7453
Published online October 2005 | e-ISSN: 1460-2091 | DOI:
Successful moxifloxacin prophylaxis against experimental streptococcal aortic valve endocarditis

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Objectives: Studies related to the prophylactic efficacy of fluoroquinolones against infective endocarditis are scarce. The aim of this study was to evaluate the efficacy of moxifloxacin, a quinolone active in vitro against Gram-positive cocci, in preventing streptococcal aortic valve endocarditis.

Methods: Non-bacterial thrombotic endocarditis of the aortic valve was induced by the insertion of a polyethylene catheter. Twenty-four hours later, rabbits were randomly assigned to a control group, and groups receiving either two doses of ampicillin (40 mg/kg, intravenously), 2 h apart, or a single dose of moxifloxacin (15 mg/kg, intravenously). Ampicillin and moxifloxacin were administered 0.5 and 1 h, respectively, prior to the intravenous inoculation of 107 cfu of Streptococcus oralis.

Results: Eighty-nine percent of the control animals developed infected vegetations. In rabbits challenged with this very high inoculum, moxifloxacin and ampicillin prevented endocarditis in 80% (P < 0.001 versus controls) and in 50% (P = 0.022 versus controls) of animals, respectively. The difference between ampicillin and moxifloxacin was not statistically significant (P = 0.128).

Conclusions: Moxifloxacin was at least as effective as ampicillin in preventing streptococcal endocarditis.

Keywords: Streptococcus oralis; fluoroquinolones; rabbits; ampicillin

Journal Article.  1953 words. 

Subjects: Medical Oncology ; Critical Care

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