Journal Article

Linezolid-associated serotonin syndrome: what we can learn from cases reported so far

José Antonio Morales-Molina, Javier Mateu-de Antonio, Mónica Marín-Casino and Santiago Grau

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 56, issue 6, pages 1176-1178
Published in print December 2005 | ISSN: 0305-7453
Published online October 2005 | e-ISSN: 1460-2091 | DOI:
Linezolid-associated serotonin syndrome: what we can learn from cases reported so far

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  • Medical Oncology
  • Critical Care


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Objectives: To study the characteristics of the linezolid-associated serotonin syndrome cases.

Methods: Database search for linezolid-associated serotonin syndrome.

Results: Twelve cases were found. The mean age of patients was 52.8 years. All patients received linezolid concomitantly with selective serotonin re-uptake inhibitor drugs (SSRID). The onset of syndrome was 9.5 days after linezolid introduction and was directly correlated to patients' age (P = 0.024). The symptoms resolved in 2.9 days. Citalopram was associated with a delayed resolution (P = 0.018). A trend was observed towards longer resolution time the longer the half-life of the interacting drug (P = 0.096).

Conclusions: Patients are at risk when receiving SSRID concomitant with linezolid. The syndrome onset could be delayed in older patients. The resolution could be delayed when citalopram is involved in the syndrome.

Keywords: citalopram; oxazolidinones; serotonin uptake inhibitors

Journal Article.  1930 words. 

Subjects: Medical Oncology ; Critical Care

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