Journal Article

Pharmacokinetics of imipenem in healthy volunteers following administration by 2 h or 0.5 h infusion

Sutep Jaruratanasirikul, Nuntida Raungsri, Jarurat Punyo and Somchai Sriwiriyajan

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 56, issue 6, pages 1163-1165
Published in print December 2005 | ISSN: 0305-7453
Published online October 2005 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dki375
Pharmacokinetics of imipenem in healthy volunteers following administration by 2 h or 0.5 h infusion

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Objectives: The aim of this study was to demonstrate the t > MIC of 0.5 and 1 g of imipenem when administered by 2 h infusion every 6 h compared with 0.5 g of imipenem when administered by 0.5 h infusion every 6 h.

Methods: The study was a randomized three-way crossover study with a 30 h wash-out period in eight healthy volunteers. Each subject received imipenem in three regimens: (i) a 0.5 h infusion of 0.5 g every 6 h for three doses; (ii) a 2 h infusion of 0.5 g every 6 h for three doses; and (iii) a 2 h infusion of 1 g every 6 h for three doses.

Results: Following 0.5 h infusion of 0.5 g, the percentages of time above four times an MIC of 4, 2 and 1 mg/L were 21.5 ± 2.2%, 38.6 ± 3.5% and 57.5 ± 4% of a 6 h interval, respectively. For the 2 h infusion of 0.5 g, the percentages of time above four times an MIC of 4, 2 and 1 mg/L were 26.9 ± 8.5%, 48.0 ± 3.5% and 65.4 ± 3.2% of a 6 h interval, respectively. For the 2 h infusion of 1 g, the percentages of time above four times an MIC of 4, 2 and 1 mg/L were 51.6 ± 5.4%, 67.8 ± 4.5% and 87.8 ± 5.6% of a 6 h interval, respectively.

Conclusions: A 2 h infusion resulted in a greater t > MIC than those after a 0.5 h infusion and intermittent infusion may be a useful mode of administration of imipenem in tropical countries.

Keywords: pharmacodynamics; β-lactams; carbapenems

Journal Article.  2044 words.  Illustrated.

Subjects: Medical Oncology ; Critical Care

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