Journal Article

Use of a new alginate film test to study the bactericidal efficacy of the high-level disinfectant <i>ortho</i>-phthalaldehyde

J. C. N. Shackelford, G. W. Hanlon and J.-Y. Maillard

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 57, issue 2, pages 335-338
Published in print February 2006 | ISSN: 0305-7453
Published online December 2005 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dki432
Use of a new alginate film test to study the bactericidal efficacy of the high-level disinfectant ortho-phthalaldehyde

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  • Medical Oncology
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Objectives: To evaluate the merit of a new alginate efficacy film test to determine the bactericidal activity of the high-level disinfectant ortho-phthalaldehyde (OPA).

Methods: The efficacy of OPA was investigated using a new sodium alginate surface film test against Mycobacterium chelonae NCIMB 1474 and Epping, and Pseudomonas aeruginosa NCIMB 10421 under different test conditions.

Results: OPA was highly bactericidal against P. aeruginosa but its mycobactericidal efficacy was seriously reduced and produced ≥5 log reductions only at a concentration of 0.5% (w/v) within 30–60 min without organic load.

Conclusions: The sodium alginate film efficacy was reproducible between repeats. Inactivation results depended upon the concentration of OPA, contact time, the presence of an organic load and the bacterial genera.

Keywords: disinfection; time-kill assay; mycobacteria; Pseudomonas aeruginosa

Journal Article.  2242 words. 

Subjects: Medical Oncology ; Critical Care

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