Journal Article

Genetic relatedness of a rarely isolated <i>Salmonella</i>: <i>Salmonella enterica</i> serotype Niakhar from NARMS animal isolates

J. D. Tankson, P. J. Fedorka-Cray, C. R. Jackson and M. Headrick

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 57, issue 2, pages 190-198
Published in print February 2006 | ISSN: 0305-7453
Published online December 2005 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dki439
Genetic relatedness of a rarely isolated Salmonella: Salmonella enterica serotype Niakhar from NARMS animal isolates

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Background: In the United States, Salmonella enterica serotype Niakhar is infrequently isolated. Between 1997 and 2000, the animal arm of the National Antimicrobial Resistance Monitoring System—Enteric Bacteria (NARMS) assayed a total of 22 383 Salmonella isolates from various animal sources (swine, cattle, chickens, turkeys, cats, horses, exotics and dogs) for antimicrobial susceptibility. Isolates originated from diagnostic and non-diagnostic submissions.

Objectives: To study the phenotypic and genotypic characteristics of Salmonella Niakhar.

Methods and results: Only five (0.02%) of the 22 383 isolates were identified as Salmonella Niakhar. Antimicrobial resistance testing indicated that three isolates were pan-susceptible, one isolate was resistant to ampicillin and one isolate was resistant to ampicillin, chloramphenicol, ciprofloxacin, kanamycin, nalidixic acid, streptomycin, sulfamethoxazole, tetracycline and trimethoprim/sulfamethoxazole. RAPD–PCR analysis, PFGE and ribotyping indicated that two pan-susceptible isolates were genetically similar, whereas the three remaining isolates were genetically different. The one Salmonella Niakhar isolate that was multiresistant harboured a class I integron, intI1 and two large plasmids.

Conclusions: This study represents the first report of a ciprofloxacin-resistant Salmonella isolate from the animal arm of NARMS.

Keywords: antimicrobial resistance; multiple drug resistance; integrons; PFGE; ribotyping

Journal Article.  6239 words.  Illustrated.

Subjects: Medical Oncology ; Critical Care

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