Journal Article

OXA-type carbapenemases

Jan Walther-Rasmussen and Niels Høiby

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 57, issue 3, pages 373-383
Published in print March 2006 | ISSN: 0305-7453
Published online January 2006 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dki482
OXA-type carbapenemases

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In recent years, the number of class D β-lactamases with carbapenem-hydrolysing properties has increased substantially. Based on amino acid sequence identities, these class D or OXA-type carbapenemases are divided into eight distantly related groups, and they are only remotely related to other class D β-lactamases. A putative ancestor to one of the plasmid-encoded OXA-type carbapenemases has been found.

OXA-type carbapenemases are not integrated into integrons as gene cassettes like many class D oxacillinases, but most of the OXA-type carbapenemases are instead encoded by chromosomal genes. Some of these OXA-type carbapenemases are widely dispersed in Pseudomonas aeruginosa and especially in Acinetobacter baumannii.

Although most of the OXA-type carbapenemases show only weak carbapenemase activity, carbapenem resistance may result from a combined action an OXA-type carbapenemase and a secondary resistance mechanism such as porin deficiencies or overexpressed efflux pumps. This article reviews the phylogeny and the genetic environments of the encoding genes and kinetic properties of the OXA-type carbapenemases.

Keywords: class D β-lactamases; carbapenem resistance; Acinetobacter baumannii; Pseudomonas aeruginosa

Journal Article.  7510 words.  Illustrated.

Subjects: Medical Oncology ; Critical Care

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