Journal Article

Decreased susceptibility to glycopeptides in methicillin-resistant <i>Staphylococcus aureus</i>: a 20 year study in a large French teaching hospital, 1983–2002

Jérôme Robert, Roland Bismuth and Vincent Jarlier

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 57, issue 3, pages 506-510
Published in print March 2006 | ISSN: 0305-7453
Published online January 2006 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dki486
Decreased susceptibility to glycopeptides in methicillin-resistant Staphylococcus aureus: a 20 year study in a large French teaching hospital, 1983–2002

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Objectives: To assess the evolution of glycopeptide susceptibility in methicillin-resistant Staphylococcus aureus (MRSA) strains isolated in a large French teaching hospital from 1983 to 2002.

Methods: Determination of glycopeptide MICs by using the Etest method in Mueller–Hinton agar on a sample of randomly selected MRSA strains.

Results: A total of 1445 MRSA strains were tested, and one vancomycin-intermediate MRSA (VISA) and 31 teicoplanin-intermediate MRSA (TISA) strains were detected. The first strains were detected in 1985, and all strains were gentamicin resistant (GR). None of the gentamicin-susceptible strains had a glycopeptide MIC > 3 mg/L. In addition, there was a significant increase in glycopeptide MIC geometric means over the years, and this increase was higher for teicoplanin than for vancomycin.

Conclusions: The higher increase in teicoplanin MICs, and the good correlation between vancomycin and teicoplanin MICs, suggests systematic determination of teicoplanin MIC to screen for abnormal glycopeptide susceptibility among GR-MRSA.

Keywords: S. aureus; vancomycin; teicoplanin; GISA; gentamicin

Journal Article.  2274 words.  Illustrated.

Subjects: Medical Oncology ; Critical Care

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