Journal Article

Daptomycin is more efficacious than vancomycin against a methicillin-susceptible <i>Staphylococcus aureus</i> in experimental meningitis

Peter Gerber, Armin Stucki, Fernando Acosta, Marianne Cottagnoud and Philippe Cottagnoud

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 57, issue 4, pages 720-723
Published in print April 2006 | ISSN: 0305-7453
Published online April 2006 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dkl007
Daptomycin is more efficacious than vancomycin against a methicillin-susceptible Staphylococcus aureus in experimental meningitis

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Objectives: To test the efficacy of daptomycin, a cyclic lipopeptide antibiotic, against a methicillin-susceptible Staphylococcus aureus strain in experimental rabbit meningitis and to determine its penetration into non-inflamed and inflamed meninges

Results: Over a treatment period of 8 h, daptomycin (15 mg/kg) was significantly superior to the comparator regimen vancomycin (−4.54 ± 1.12 log10/mL for daptomycin versus −3.43 ± 1.17 log10/mL for vancomycin). Daptomycin managed to sterilize 6 out of 10 CSFs compared with 4 out of 10 for vancomycin. The penetration of daptomycin into inflamed meninges was ∼5% and ∼2% into non-inflamed meninges.

Conclusions: The superior bactericidal activity of daptomycin was confirmed in vivo and in time-killing assays in vitro.

Keywords: bacterial meningitis; treatment; S. aureus; cyclic lipopeptide

Journal Article.  2461 words.  Illustrated.

Subjects: Medical Oncology ; Critical Care

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