Journal Article

Strategies for identification of carbapenemase-producing Enterobacteriaceae

Patrice Nordmann and Laurent Poirel

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 68, issue 3, pages 487-489
Published in print March 2013 | ISSN: 0305-7453
Published online October 2012 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dks426
Strategies for identification of carbapenemase-producing Enterobacteriaceae

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The spread of carbapenem-hydrolysing β-lactamases in Enterobacteriaceae is becoming a major public health issue. These β-lactamases hydrolyse almost all β-lactams, are plasmid-encoded and are easily transferable among enterobacterial species. They are found in multidrug-resistant isolates. Detection of these isolates from infected specimens first relies on careful recognition of any decreased susceptibility to carbapenems. After this, rapid biochemical identification of carbapenemase producers using the novel Carba NP test should be performed. Subsequently, molecular techniques can be used to identify carbapenemase genes if necessary (epidemiology). Detection of carriers relies on a preliminary screening step, with stools or rectal swabs being screened on selective culture media such as SUPERCARBA medium, which posseses the broadest spectrum for detecting any type of carbapenemase producer.

Keywords: antibiotics; carbapenems; β-lactams; resistance; Gram-negatives

Journal Article.  2093 words. 

Subjects: Medical Oncology ; Critical Care

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