Journal Article

A Simple, Reliable Method for the Determination of Chlorinated Volatile Organics in Human Breath and Air Using Glass Sampling Tubes

Vincent B. Stein, Rajinder S. Narang, Lloyd Wilson and Kenneth M. Aldous

in Journal of Analytical Toxicology

Volume 20, issue 3, pages 145-150
Published in print May 1996 | ISSN: 0146-4760
e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/20.3.145
A Simple, Reliable Method for the Determination of Chlorinated Volatile Organics in Human Breath and Air Using Glass Sampling Tubes

More Like This

Show all results sharing these subjects:

  • Medical Toxicology
  • Toxicology (Non-medical)

GO

Show Summary Details

Preview

A method for determining chloroform, 1,1,1-trichloroethane, carbon tetrachloride, and trichloroethene in breath samples was developed. It consisted of collecting samples in 40-mL glass-silanized tubes that were 16-in. long and had a 0.64-in. diameter. The ends tapered, resulting in a tube with a ¼-in. diameter that was 1¾-in. long; each end had a shutoff valve attached. One end had a strip of rubber tube attached to the shutoff valve for collecting the breath sample, and the other end contained a ¼-in. Swagelok nut with a rubber septum for withdrawing the sample. Samples were withdrawn using a pressure-lock, gastight syringe, and they were injected onto a gas chromatograph fitted with an electron-capture detector. The analytes were stable for at least 22 days in these tubes. The method detection limit was determined to be 0.03, 0.08, 0.04, and 0.04 pg/mL for chloroform, 1,1,1-trichloroethane, carbon tetrachloride, and trichloroethene, respectively. Precision, based on 13 injections, was determined to be 13% for 0.09 pg chloroform, 13% for 0.21 pg 1,1,1-trichloroethane, 8% for 0.16 pg carbon tetrachloride, and 14% for 0.1 pg trichloroethene. In all, the proposed method is a sensitive and reliable one for determining volatile organic compounds in breath and a method that can also be applied to air sampling.

Journal Article.  0 words. 

Subjects: Medical Toxicology ; Toxicology (Non-medical)

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.