Journal Article

Determination of Gabapentin in Serum Using Solid-Phase Extraction and Gas-Liquid Chromatography

Carl E. Wolf, Joseph I. Saady and Alphonse Poklis

in Journal of Analytical Toxicology

Volume 20, issue 6, pages 498-501
Published in print October 1996 | ISSN: 0146-4760
e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/20.6.498
Determination of Gabapentin in Serum Using Solid-Phase Extraction and Gas-Liquid Chromatography

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A gas-liquid chromatographic method for the determination of gabapentin (Neurontin®) is described. The method involves extracting 0.5 mL of acidified sample by C18 solid-phase column, derivatization with MTBSTFA plus 1% tBDMCS, and analysis on an HP-1 column with a flame-ionization detector. Quantitation was performed with peak-height ratios of gabapentin to a gabapentin analogue [(1-aminomethyl-1-cycloheptyl) acetic acid] as the internal standard. The assay had a limit of detection of 0.2 mg/L and a linear range from 0.5 to 30.0 mg/L. Several compounds were analyzed for potential interference, and none interfered with the assay.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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