Journal Article

Fetal Cocaine Exposure: Analysis of Vernix Caseosa

Christine Moore, Delia Dempsey, Dawn Deitermann, Douglas Lewis and Jerrold Leikin

in Journal of Analytical Toxicology

Volume 20, issue 6, pages 509-511
Published in print October 1996 | ISSN: 0146-4760
e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/20.6.509
Fetal Cocaine Exposure: Analysis of Vernix Caseosa

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Preliminary data regarding the use of vernix caseosa (VC) as an alternative to other biological specimens for the determination of fetal cocaine exposure are presented. Advantages of VC analysis include its presence on all newborn babies, historical record of drug exposure, and ease of collection and storage. Fifteen samples of vernix caseosa—five from babies known to be cocaine-exposed because of a positive benzoylecgonine result from the urine and umbilical cord blood and ten from nonexposed neonates—were analyzed for the presence of cocaine and metabolites. VC samples from three of the five neonates known to be cocaine-exposed were positive for cocaine or its metabolites, the other two had little or no remaining specimen. The remaining ten were negative.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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