Journal Article

A Simple and Sensitive Quantitation of <i>N,N</i>-Dimethyltryptamine by Gas Chromatography with Surface Ionization Detection

Akira Ishii, Hiroshi Seno, Osamu Suzuki, Hideki Hattori and Takeshi Kumazawa

in Journal of Analytical Toxicology

Volume 21, issue 1, pages 36-40
Published in print January 1997 | ISSN: 0146-4760
Published online January 1997 | e-ISSN: 1945-2403 | DOI:
A Simple and Sensitive Quantitation of N,N-Dimethyltryptamine by Gas Chromatography with Surface Ionization Detection

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  • Medical Toxicology
  • Toxicology (Non-medical)


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A simple and sensitive method for determination of N,N-dimethyltryptamine (DMT) by gas chromatography (GC) with surface ionization detection (SID) is presented. Whole blood or urine, containing DMT and gramine (internal standard), was subjected to solid-phase extraction with a Sep-Pak C18 cartridge before analysis by GC-SID. The calibration curve was linear in the DMT range of 1.25–20 ng/mL blood or urine. The detection limit of DMT was about 0.5 ng/mL (10 pg on-column). The recovery of both DMT and gramine spiked in biological fluids was above 86%.

Journal Article.  0 words. 

Subjects: Medical Toxicology ; Toxicology (Non-medical)

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