Journal Article

Time-Lapse Changes of <i>d</i>- and <i>l</i>-Enantiomers of Racemic (<i>dl</i>)-Ethylamphetamine in Human Urine

Toshiaki Nagai, Hideaki Kanaya, Kazumi Matsushima and Shigetaro Kamiyama

in Journal of Analytical Toxicology

Volume 21, issue 2, pages 112-115
Published in print March 1997 | ISSN: 0146-4760
Published online March 1997 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/21.2.112
Time-Lapse Changes of d- and l-Enantiomers of Racemic (dl)-Ethylamphetamine in Human Urine

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The time-lapse changes of d- and l-forms in urine specimens collected in the 24 h after the oral dosing of two adult male subjects with 20 mg of racemic (dl)-ethylamphetamine (EAMP)-HCI were examined by high-performance liquid chromatography. The percentage of the excreted dose of nonmetabolized l-EAMP was larger than that of d-EAMP, and the percentage of the excreted dose of metabolized l-amphetamine (AMP) was smaller than that of d-AMP in both subjects, A and B. These differences were observed 4.5–24 h after administration of the drug. The changes in the l/d ratio of EAMP and AMP were not similar between subjects A and B, but the change in the total l/d ratio was nearly the same. The regression line for subject A was as follows: y = 0.021323x + 0.98399. The regression line for subject B was as follows: y = 0.020947x + 0.94893. These two regression lines suggested that the time lapsed after the administration to humans could be predicted. The total percent of the excreted doses of EAMP and AMP was 47.46% (the d-forms, 20.73%; the l-forms, 26.73%) for subject A and was 31.43% (the d-forms, 14.14%; the l-forms, 17.29%) for subject B. The l/d ratio was 1.29 for subject A and 1.22 for subject B, which was somewhat higher than that (1.01) of the dl-EAMP-HCI used.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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