Journal Article

Verification of Exposure to Sulfur Mustard in Two Casualties of the Iran-Iraq Conflict

Hendrik P. Benschop, Govert P. van der Schans, Daan Noort, Alex Fidder, Roos H. Mars-Groenendijk and Leo P.A. de Jong

in Journal of Analytical Toxicology

Volume 21, issue 4, pages 249-251
Published in print July 1997 | ISSN: 0146-4760
Published online July 1997 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/21.4.249
Verification of Exposure to Sulfur Mustard in Two Casualties of the Iran-Iraq Conflict

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The exposure of two Iranian victims of the Iran-Iraq conflict (1980–1988) to sulfur mustard was established by immunochemical and mass spectrometric analysis of blood samples taken 22 and 26 days after the alleged exposure. One victim suffered from skin injuries compatible with sulfur mustard intoxication but did not have lung injuries; the symptoms of the other victim were only vaguely compatible with sulfur mustard intoxication. Both patients recovered. Immunochemical analysis was based on detection of the N7-guanine adduct of the agent in DNA from lymphocytes and granulocytes, whereas the N-terminal valine adduct in globin was determined by gas chromatography-mass spectrometry after a modified Edman degradation. The valine adduct levels correspond with those found in human blood after in vitro treatment with 0.9µM sulfur mustard.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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