Journal Article

Solid-Phase Extraction in Amphetamine and Methamphetamine Analysis of Urine

Maw-Rong Lee, Sheng-Chien Yu, Ching-Lin Lin, Yao-Chia Yeh, Yung-Lin Chen and Shih-Hsiung Hu

in Journal of Analytical Toxicology

Volume 21, issue 4, pages 278-282
Published in print July 1997 | ISSN: 0146-4760
Published online July 1997 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/21.4.278
Solid-Phase Extraction in Amphetamine and Methamphetamine Analysis of Urine

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A systematic evaluation that compares the recoveries of methamphetamine and amphetamine from spiked urine using C8, C18, strong cation exchanger (SCX), and C8-SCX mixed procedures (solid-phase extraction) is reported. Optimized experimental conditions including pH of the sample, solvent composition, and urine concentration for different solid-phase extraction sorbents were studied. The largest recoveries—greater than 86% for methamphetamine and greater than 88% for amphetamine—were achieved with a mixed adsorbent (C8-SCX) and mixed elution solvent CH2CI2-i-propanol-NH4OH (78:20:2) at pH 6. The concentration of the urine matrix did not affect the extraction efficiency. The detection limits of methamphetamine and amphetamine in urine were obtained at 0.03 and 0.07 µg/mL, respectively, using gas chromatographic-mass spectrometric analysis operated in the electron impact mode.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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