Journal Article

Development of a Supercritical Fluid Extraction Method for the Determination of Temazepam in Whole Blood

Karen S. Scott and John S. Oliver

in Journal of Analytical Toxicology

Volume 21, issue 4, pages 297-300
Published in print July 1997 | ISSN: 0146-4760
Published online July 1997 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/21.4.297
Development of a Supercritical Fluid Extraction Method for the Determination of Temazepam in Whole Blood

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A supercritical fluid extraction (SFE) procedure for the analysis of temazepam from whole blood was developed. Quantitative recoveries were obtained by high-performance liquid chromatography using prazepam as an internal standard and carefully monitoring the extraction temperature and pressure. The results were found to compare well with those obtained by solid-phase extraction techniques, but they also had the advantages of reduced solvent consumption and minimal sample handling. The application of this method to authentic forensic blood specimens showed the SFE method to he useful as an alternative procedure for the extraction of temazepam in the toxicology laboratory.

Journal Article.  0 words. 

Subjects: Medical Toxicology ; Toxicology (Non-medical)

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