Journal Article

Excretion of Cannabinoids in Urine after Ingestion of Cannabis Seed Oil

T. Lehmann, F. Sager and R. Brenneisen

in Journal of Analytical Toxicology

Volume 21, issue 5, pages 373-375
Published in print September 1997 | ISSN: 0146-4760
Published online September 1997 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/21.5.373
Excretion of Cannabinoids in Urine after Ingestion of Cannabis Seed Oil

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Gas chromatographic-mass spectrometric (GC-MS) quantitation of 25 cannabis sed oils determined Δ9-tetrahydrocannabinol (THC) concentrations from 3 to 1500 µg/g oil. In a pilot study, the morning urine of six volunteers who had ingested 11 or 22 g of the oil, which contained the highest THC content (1500 µg/g), was collected for six days. The urine samples were screened by immunoassay, and the content of 11-nor-9-carboxy-Δ9-THC (THCCOOH) was determined by GC-MS. Urine samples were found cannabis positive for up to six days with THCCOOH-equivalent concentrations up to 243 ng/ml, by the Abuscreen OnLine immunoassay and THCCOOH contents from 5 to 431 ng/mL by the GC-MS method. All subjects reported THC-specific psychotropic effects.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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