Journal Article

Incorporation of Isotopically Labeled Cocaine into Human Hair: Race as a Factor

Gary L. Henderson, Martha R. Harkey, Chihong Zhou, Reese T. Jones and Peyton Jacob

in Journal of Analytical Toxicology

Volume 22, issue 2, pages 156-165
Published in print March 1998 | ISSN: 0146-4760
Published online March 1998 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/22.2.156
Incorporation of Isotopically Labeled Cocaine into Human Hair: Race as a Factor

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In order to evaluate race as a possible factor affecting the incorporation of drugs into human hair, 2 mg/kg deuterium-labeled cocaine (cocaine-d5) was administered intranasally to nine male non-Caucasian volunteers under controlled laboratory conditions. Sequential blood samples were collected for up to three days, and scalp hair samples were collected at 24 and 72 h after dosing and at monthly intervals for up to 12 months. The samples were then analyzed by gas chromatography-mass spectrometry for cocaine-d5 and benzoylecgonine-d5 (BZE-d5). The amounts of cocaine-d5 found in the hair of these non-Caucasian subjects were compared with the amounts of cocaine-d5 found in the hair of Caucasian subjects who received the same cocaine dose under identical conditions as part of a study we reported previously. The non-Caucasians in the present study had approximately 2.7 times more cocaine-d5 in their hair than the Caucasian subjects in the earlier study. In five of the non-Caucasian subjects, cocaine-d5 could be detected in hair within 24 h after dosing. Curiously, we were unable to detect any cocaine-d5 in one of the non-Caucasian subject's hair at any time after dosing even though cocaine-d5 was in plasma at the expected levels. The results from these studies suggest there may be a racial bias in the incorporation of cocaine into human hair; however, the data are not conclusive because of the relatively small sample size.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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