Journal Article

Identification of Metabolites of Nerve Agent VX in Serum Collected from a Victim

Hitoshi Tsuchihashi, Munehiro Katagi, Mayumi Nishikawa and Michiaki Tatsuno

in Journal of Analytical Toxicology

Volume 22, issue 5, pages 383-388
Published in print September 1998 | ISSN: 0146-4760
Published online September 1998 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/22.5.383
Identification of Metabolites of Nerve Agent VX in Serum Collected from a Victim

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A human serum sample collected from a victim of the Osaka VX incident was analyzed according to our developed technique for metabolites of VX. Gas chromatography-mass spectrometry (GC-MS) in full-scan electron impact and chemical ionization modes were used, and, for more reliable confirmation, GC-MS-MS was also employed. In the serum sample, both ethyl methylphosphonic acid and 2-(diisopropylamino-ethyl)methyl sulfide were detected. These results indicated that the techniques using GC-MS and GC-MS-MS were applicable to biological samples such as serum. These results also provide the first documented, unequivocal identification of the specific metabolites of VX in victim's serum and, furthermore, clarify a part of the metabolic pathway of VX in the human body.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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