Journal Article

The Measurement of Nitrite in Adulterated Urine Samples by High-Performance Ion Chromatography

Jasbir Singh, James A. Elberling, D. Gary Hemphill and Jeffrey Holmstrom

in Journal of Analytical Toxicology

Volume 23, issue 3, pages 137-140
Published in print May 1999 | ISSN: 0146-4760
Published online May 1999 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/23.3.137
The Measurement of Nitrite in Adulterated Urine Samples by High-Performance Ion Chromatography

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With the increased availability of nitrite-containing commercial products that are used for the adulteration of urine samples in the workplace, it is necessary for laboratories to be able to detect and confirm the presence of nitrite in these samples. We have developed a method to confirm the presence of nitrite in urine samples. The method uses the IonPac AS 14 analytical column with the Dionex series 45001 Bio LC system equipped with an anion self-generating suppressor and conductivity detector. Using a single-point calibration, the method is linear and accurately quantitates nitrite to 12,000 µg/mL. The limit of detection is 30 µg/mL, and the day-to-day precision of the assay has a coefficient of variation (CV) of 4.3% at 1200 µg/mL and 3.8% at 2700 µg/mL of nitrite.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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